Protein factors in pre-mRNA 3′-end processing
CR Mandel, Y Bai, L Tong - Cellular and Molecular Life Sciences, 2008 - Springer
Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
Pre‐mRNA 3′‐end processing complex assembly and function
S Chan, EA Choi, Y Shi - Wiley Interdisciplinary Reviews: RNA, 2011 - Wiley Online Library
The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …
[HTML][HTML] Molecular architecture of the human pre-mRNA 3′ processing complex
Y Shi, DC Di Giammartino, D Taylor, A Sarkeshik… - Molecular cell, 2009 - cell.com
Pre-mRNA 3′ end formation is an essential step in eukaryotic gene expression. Over half of
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …
Structure of an active human histone pre-mRNA 3′-end processing machinery
The 3′-end processing machinery for metazoan replication-dependent histone precursor
messenger RNAs (pre-mRNAs) contains the U7 small nuclear ribonucleoprotein and shares …
messenger RNAs (pre-mRNAs) contains the U7 small nuclear ribonucleoprotein and shares …
[HTML][HTML] Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation
Identification of novel cellular proteins as substrates to viral proteases would provide a new
insight into the mechanism of cell–virus interplay. Eight nuclear proteins as potential targets …
insight into the mechanism of cell–virus interplay. Eight nuclear proteins as potential targets …
[HTML][HTML] Activation of the endonuclease that defines mRNA 3′ ends requires incorporation into an 8-subunit core cleavage and polyadenylation factor complex
Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein complex essential for
formation of eukaryotic mRNA 3ʹ ends. CPF cleaves pre-mRNAs at a specific site and adds …
formation of eukaryotic mRNA 3ʹ ends. CPF cleaves pre-mRNAs at a specific site and adds …
[HTML][HTML] Poly (A) signal-dependent transcription termination occurs through a conformational change mechanism that does not require cleavage at the poly (A) site
Transcription termination for genes encoding polyadenylated mRNAs requires a functional
poly (A) signal (PAS) in the nascent pre-mRNA. Often called PAS-dependent termination, or …
poly (A) signal (PAS) in the nascent pre-mRNA. Often called PAS-dependent termination, or …
Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing
K Martincic, SA Alkan, A Cheatle, L Borghesi… - Nature …, 2009 - nature.com
Immunoglobulin secretion is modulated by competition between the use of a weak promoter-
proximal poly (A) site and a nonconsensus splice site in the final secretory-specific exon of …
proximal poly (A) site and a nonconsensus splice site in the final secretory-specific exon of …
Functional coupling of last-intron splicing and 3′-end processing to transcription in vitro: the poly (A) signal couples to splicing before committing to cleavage
F Rigo, HG Martinson - Molecular and cellular biology, 2008 - Am Soc Microbiol
We have developed an in vitro transcription system, using HeLa nuclear extract, that
supports not only efficient splicing of a multiexon transcript but also efficient cleavage and …
supports not only efficient splicing of a multiexon transcript but also efficient cleavage and …
Delineating the structural blueprint of the pre-mRNA 3′-end processing machinery
Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …