The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire
body. This sustained inflammatory state disrupts the coordinated communication between …

Neurofilament light chain (NfL) is a novel biomarker reflecting neuroaxonal damage and
associates with brain atrophy, and glial fibrillary acidic protein (GFAP) is a marker of …

Hypothalamic astrocytes are particularly affected by energy‐dense food consumption. How
the anatomical location of these glial cells and their spatial molecular distribution in the …

A decrease in the activity of the insulin signaling system of the brain, due to both central
insulin resistance and insulin deficiency, leads to neurodegeneration and impaired …

Astrocytes, the predominant glial cell type in the mammalian brain, influence a wide variety
of brain parameters including neuronal energy metabolism. Exciting recent studies have …

Evidence for involvement of the central nervous system (CNS) in the regulation of glucose
metabolism dates back to the 19th century, although the majority of the research on glucose …

Hypothalamus is a brain region that controls food intake and energy expenditure while
sensing signals that convey information about energy status. Within the hypothalamus …

Abstract Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early
dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may …

The central control of energy homeostasis is a regulatory axis that involves the sensing of
nutrients, signaling molecules, adipokines, and neuropeptides by neurons in the metabolic …