The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …

Alzheimer's disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …

The cerebellum has long been regarded as essential only for the coordination of voluntary
motor activity and motor learning. Anatomical, clinical and neuroimaging studies have led to …

Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

It has been known for decades that degeneration of the locus coeruleus (LC), the major
noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

PURPOSE OF REVIEW Alzheimer disease (AD) is the most common cause of late-onset
dementia. This article describes the epidemiology, genetic and environmental risk factors …

Alzheimer's disease (AD) is the most common cause of dementia, affecting the central
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …