[HTML][HTML] The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality
Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
Post-translational modifications: regulators of neurodegenerative proteinopathies
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several
other neurodegenerative diseases known as synucleinopathies. The toxic properties of α …
other neurodegenerative diseases known as synucleinopathies. The toxic properties of α …
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Sirtuin genes have been associated with aging and are known to affect multiple cellular
pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age …
pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age …
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …
Huntington's disease, present challenges in healthcare because of their complicated …
Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease
JM Bourgognon, JG Spiers… - Proceedings of the …, 2021 - National Acad Sciences
Several neurodegenerative diseases associated with protein misfolding (Alzheimer's and
Parkinson's disease) exhibit oxidative and nitrergic stress following initiation of …
Parkinson's disease) exhibit oxidative and nitrergic stress following initiation of …
Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes
A Chegão, M Guarda, BM Alexandre… - npj Parkinson's …, 2022 - nature.com
Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to
its accumulation in typical protein aggregates in the brain. However, it is still unclear how it …
its accumulation in typical protein aggregates in the brain. However, it is still unclear how it …
Alpha-synuclein glycation and the action of anti-diabetic agents in Parkinson's disease
A Koenig, H Vicente Miranda… - Journal of Parkinson's …, 2018 - content.iospress.com
Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology and
variable pathology. While a subset of cases is associated with single-gene mutations, the …
variable pathology. While a subset of cases is associated with single-gene mutations, the …
Studying Huntington's disease in yeast: from mechanisms to pharmacological approaches
Huntington's disease (HD) is a neurodegenerative disorder that leads to progressive
neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD …
neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD …
[HTML][HTML] Hypoxia-induced degenerative protein modifications associated with aging and age-associated disorders
Aging is an inevitable time-dependent decline of various physiological functions that finally
leads to death. Progressive protein damage and aggregation have been proposed as the …
leads to death. Progressive protein damage and aggregation have been proposed as the …