Non-viral vectors for RNA delivery
Y Yan, XY Liu, A Lu, XY Wang, LX Jiang… - Journal of Controlled …, 2022 - Elsevier
RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …
The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine
Nanoparticle-based therapeutics and diagnostics are commonly referred to as
nanomedicine and may significantly impact the future of healthcare. However, the clinical …
nanomedicine and may significantly impact the future of healthcare. However, the clinical …
Organelle-level precision with next-generation targeting technologies
Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …
therapy has received significant attention since the inception, due to its ability to efficiently …
Advanced strategies for overcoming endosomal/lysosomal barrier in nanodrug delivery
C Qiu, F Xia, J Zhang, Q Shi, Y Meng, C Wang, H Pang… - Research, 2023 - spj.science.org
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …
Uptake of engineered gold nanoparticles into mammalian cells
LA Dykman, NG Khlebtsov - Chemical reviews, 2014 - ACS Publications
In the past decade, mammalian cells have increasingly encountered gold nanoparticles
(GNPs), owing to the active development of nanomedicine. 1− 3 GNPs have been more and …
(GNPs), owing to the active development of nanomedicine. 1− 3 GNPs have been more and …
Chondroitin sulfate-linked prodrug nanoparticles target the golgi apparatus for cancer metastasis treatment
H Li, P Zhang, J Luo, D Hu, Y Huang, ZR Zhang, Y Fu… - Acs Nano, 2019 - ACS Publications
Metastasis is a multistep biological process regulated by multiple signaling pathways. The
integrity of the Golgi apparatus plays an important role in these signaling pathways. Inspired …
integrity of the Golgi apparatus plays an important role in these signaling pathways. Inspired …
Future of nanotherapeutics: Targeting the cellular sub-organelles
Many diseases originate from alterations at nanoscale levels. Precise drug delivery should
be achieved not only at cell level, but also at organelle level to achieve maximum …
be achieved not only at cell level, but also at organelle level to achieve maximum …
Recent advances in drug delivery systems for targeting brain tumors
Y Zhao, P Yue, Y Peng, Y Sun, X Chen, Z Zhao… - Drug delivery, 2023 - Taylor & Francis
Brain tumor accounts for about 1.6% of incidence and 2.5% of mortality of all tumors, and the
median survival for brain tumor patients is only about 20 months. The treatment for brain …
median survival for brain tumor patients is only about 20 months. The treatment for brain …