The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

The multivesicular body (MVB) pathway is responsible for both the biosynthetic delivery of
lysosomal hydrolases and the downregulation of numerous activated cell surface receptors …

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …

The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell
differentiation and proliferation upon activation through the binding of one of its ligands. The …

Receptor desensitization is accomplished by accelerated endocytosis and degradation of
ligand–receptor complexes. An in vitro reconstituted system indicates that Cbl adaptor …

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …

Deregulation of signaling by the epidermal growth factor receptor (EGFR) is common in
human malignancy progression. One mutant EGFR (variously named ΔEGFR, de2-7 EGFR …