Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests
clinically as an isolated amnestic deficit that progresses to a characteristic dementia …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

Purpose To compare quantitative cerebral blood flow (CBF) values in patients with
Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and subjects with …

Arterial spin labeling (ASL) magnetic resonance imaging uses arterial blood water as an
endogenous tracer to measure cerebral blood flow (CBF). In this review, based on ASL …

There is growing recognition that cerebral hypoperfusion is related to the pathogenesis of
Alzheimer's disease (AD), implicating the measurement of cerebral blood flow (CBF) as a …

Patients with Alzheimer's disease have reduced cerebral blood flow measured by arterial
spin labelling magnetic resonance imaging, but it is unclear how this is related to amyloid-β …

Background: The incidence of dementia is projected to rise over the coming decades, but
with no sensitive diagnostic tests available. Vascular pathology precedes the deposition of …

The role of hypoperfusion in Alzheimer's disease (AD) is a vital component to understanding
the pathogenesis of this disease. Disrupted perfusion is not only evident throughout disease …

Arterial spin labeling (ASL) enables the noninvasive, quantitative imaging of cerebral blood
flow using standard magnetic resonance imaging (MRI) equipment. Because it requires no …