In recent years, Dictyostelium discoideum has become an important model organism to
study the cell biology of professional phagocytes. This amoeba not only shares many …

Preserving genome integrity through repair of DNA damage is critical for human health and
defects in these pathways lead to a variety of pathologies, most notably cancer. The social …

Although serine ADP-ribosylation (Ser-ADPr) by Poly (ADP-ribose)-polymerases is a
cornerstone of the DNA damage response, how this regulates DNA repair and genome …

Lamins build the nuclear lamina and are required for chromatin organization, gene
expression, cell cycle progression, and mechanical stabilization. Despite these universal …

Fast amoeboid migration requires cells to apply mechanical forces on their surroundings via
transient adhesions. However, the role these forces play in controlling cell migration speed …

Background The evolution of multicellularity is a critical event that remains incompletely
understood. We use the social amoeba, Dictyostelium discoideum, one of the rare …

The social amoeba Dictyostelium discoideum provides an excellent model for research
across a broad range of disciplines within biology. The organism diverged from the plant …

Hydroxamate-based lysine deacetylase inhibitors (KDACis) are approved for clinical use
against certain cancers. However, intrinsic and acquired resistance presents a major …

ADP-ribosyltransferases (ARTs) modify proteins with single units or polymers of ADP-ribose
to regulate DNA repair. However, the substrates for these enzymes are ill-defined. For …

In vivo, cells navigate through complex environments filled with obstacles such as other cells
and the extracellular matrix. Recently, the term" topotaxis" has been introduced for …