The α‐arrestin family of ubiquitin ligase adaptors links metabolism with selective endocytosis
The regulation of nutrient uptake into cells is important, as it allows to either increase
biomass for cell growth or to preserve homoeostasis. A key strategy to adjust cellular nutrient …
biomass for cell growth or to preserve homoeostasis. A key strategy to adjust cellular nutrient …
Fungal plasma membrane domains
A Athanasopoulos, B Andre… - FEMS microbiology …, 2019 - academic.oup.com
The plasma membrane (PM) performs a plethora of physiological processes, the
coordination of which requires spatial and temporal organization into specialized domains of …
coordination of which requires spatial and temporal organization into specialized domains of …
Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity
Y Alguel, S Amillis, J Leung, G Lambrinidis… - Nature …, 2016 - nature.com
The uric acid/xanthine H+ symporter, UapA, is a high-affinity purine transporter from the
filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a …
filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a …
Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases
K Ghaddar, A Merhi, E Saliba… - … and cellular biology, 2014 - Am Soc Microbiol
Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and
delivery to the lysosome in response to various stimuli. We report here that two amino acid …
delivery to the lysosome in response to various stimuli. We report here that two amino acid …
Transition of yeast Can1 transporter to the inward-facing state unveils an α-arrestin target sequence promoting its ubiquitylation and endocytosis
Substrate-transport–elicited endocytosis is a common control mechanism of membrane
transporters avoiding excess uptake of external compounds, though poorly understood at …
transporters avoiding excess uptake of external compounds, though poorly understood at …
[HTML][HTML] Endocytosis and early endosome motility in filamentous fungi
G Steinberg - Current opinion in microbiology, 2014 - Elsevier
Highlights•Early endosomes in filamentous fungi move along microtubules.•In several fungi,
endosome motility is mediated by kinesin-3 and dynein.•In Ustilago and Aspergillus, a Hook …
endosome motility is mediated by kinesin-3 and dynein.•In Ustilago and Aspergillus, a Hook …
Endocytosis in filamentous fungi: Cinderella gets her reward
MÁ Peñalva - Current opinion in microbiology, 2010 - Elsevier
Endocytosis has been the Cinderella of membrane trafficking studies in filamentous fungi
until recent work involving genetically tractable models has boosted interest in the field …
until recent work involving genetically tractable models has boosted interest in the field …
Tales of tails in transporters
E Mikros, G Diallinas - Open Biology, 2019 - royalsocietypublishing.org
Cell nutrition, detoxification, signalling, homeostasis and response to drugs, processes
related to cell growth, differentiation and survival are all mediated by plasma membrane …
related to cell growth, differentiation and survival are all mediated by plasma membrane …
Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters
G Diallinas - Frontiers in pharmacology, 2014 - frontiersin.org
Transporters are ubiquitous proteins mediating the translocation of solutes across cell
membranes, a biological process involved in nutrition, signaling, neurotransmission, cell …
membranes, a biological process involved in nutrition, signaling, neurotransmission, cell …
Origin, diversification and substrate specificity in the family of NCS 1/FUR transporters
NCS 1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and
related metabolites. In this article, we study the origin, diversification and substrate specificity …
related metabolites. In this article, we study the origin, diversification and substrate specificity …