Skin senescence: mechanisms and impact on whole-body aging

AC Franco, C Aveleira, C Cavadas - Trends in molecular medicine, 2022 - cell.com
The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

Alopecia areata: a review of disease pathogenesis

F Rajabi, LA Drake, MM Senna… - British Journal of …, 2018 - academic.oup.com
Background Alopecia areata is a disorder that results in nonscarring hair loss. The
psychological impact can be significant, leading to feelings of depression and social …

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

S Choi, B Zhang, S Ma, M Gonzalez-Celeiro, D Stein… - Nature, 2021 - nature.com
Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although
the mechanisms by which these changes occur are largely unknown. Here we report that the …

Key role of CRF in the skin stress response system

AT Slominski, MA Zmijewski, B Zbytek… - Endocrine …, 2013 - academic.oup.com
The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

The autoimmune basis of alopecia areata: a comprehensive review

N Islam, PSC Leung, AC Huntley, ME Gershwin - Autoimmunity reviews, 2015 - Elsevier
Alopecia areata (AA) is a common, non-scarring dermatologic condition regularly
distinguished by patches of hair loss on the scalp also manifesting in other, severe forms …

[HTML][HTML] Integrative and mechanistic approach to the hair growth cycle and hair loss

N Natarelli, N Gahoonia, RK Sivamani - Journal of clinical medicine, 2023 - mdpi.com
The hair cycle is composed of four primary phases: anagen, catagen, telogen, and exogen.
Anagen is a highly mitotic phase characterized by the production of a hair shaft from the hair …

[HTML][HTML] Neuroimmunology of stress: skin takes center stage

PC Arck, A Slominski, TC Theoharides… - Journal of Investigative …, 2006 - Elsevier
Like few other organs, the skin is continuously exposed to multiple exogenous and
endogenous stressors. Superimposed on this is the impact of psychological stress on skin …

Alopecia areata: an autoimmune disease of multiple players

P Suchonwanit, C Kositkuljorn… - ImmunoTargets and …, 2021 - Taylor & Francis
Alopecia areata (AA) is an autoimmune disease of the hair follicles. It is characterized by a
well-defined non-scarring alopecic patch or patches that may extend to the entire scalp or …

Telogen effluvium: a comprehensive review

A Rebora - Clinical, cosmetic and investigational dermatology, 2019 - Taylor & Francis
Excessive hair shedding is a common and alarming phenomenon, usually complained
about by women. The disorder, named telogen effluvium (TE), bears several problems which …

[PDF][PDF] Biology of the hair follicle: the basics

K Krause, K Foitzik - Seminars in cutaneous medicine and …, 2006 - scmsjournal.com
The mammalian hair follicle represents a unique, highly regenerative neuroectodermal–
mesodermal interaction system that contains numerous stem cells. It is the only organ in the …