The transformation from normal to malignant phenotype in human cancers is associated with
aberrant cell-surface glycosylation. It has frequently been reported that MUC1, the heavily …

Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant
microorganisms. Numerous natural nucleosides and their synthetically modified analogues …

The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial
pathogens have demanded the discovery and development of new antibacterial agents. A …

Binary fission is the most common mode of bacterial cell division and is mediated by a
multiprotein complex denominated the divisome. The constriction of the Z-ring splits the …

Proteins involved in bacterial cell division often do not have a counterpart in eukaryotic cells
and they are essential for the survival of the bacteria. The genetic accessibility of many …

The global spread of bacterial antimicrobial resistance is associated to millions of deaths
from bacterial infections per year, many of which were previously treatable. This, combined …

Naturally occurring phytochemicals with reported antibacterial activity were screened for
their ability to inhibit the bacterial cell division protein Escherichia coli FtsZ. Among the …

FtsZ is a self-assembling GTPase that forms, below the inner membrane, the mid-cell Z-ring
guiding bacterial division. FtsZ monomers polymerize head to tail forming tubulin-like …

Emerging drug resistance and other drawbacks limit tubulin inhibitors' therapeutic
applications and developing novel tubulin inhibitors still attracts intensive efforts. We …

The rapid emergence of methicillin-resistant Staphylococcus aureus (MRSA) strains has
undermined the therapeutic efficacy of existing β-lactam antibiotics (BLAs), prompting an …