New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Proteases involved in leader peptide removal during RiPP biosynthesis

SM Eslami, WA van der Donk - ACS Bio & Med Chem Au, 2023 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) have received
much attention in recent years because of their promising bioactivities and the portability of …

Unveiling the biosynthetic pathway of the ribosomally synthesized and post‐translationally modified peptide ustiloxin B in filamentous fungi

Y Ye, A Minami, Y Igarashi, M Izumikawa… - Angewandte …, 2016 - Wiley Online Library
The biosynthetic machinery of the first fungal ribosomally synthesized and post‐
translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene …

Linaridin natural products

S Ma, Q Zhang - Natural Product Reports, 2020 - pubs.rsc.org
Covering: 1993 up to May 2020 Linaridins, defined as linear, dehydrated (arid) peptides, are
a small but growing family of natural products belonging to the ribosomally synthesized and …

Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review

V Uka, JW Cary, MD Lebar, O Puel… - … Reviews in Food …, 2020 - Wiley Online Library
Filamentous fungi represent a rich source of extrolites, including secondary metabolites
(SMs) comprising a great variety of astonishing structures and interesting bioactivities. State …

Heterologous biosynthesis as a platform for producing new generation natural products

D Park, G Swayambhu, BA Pfeifer - Current Opinion in Biotechnology, 2020 - Elsevier
Highlights•Natural products include numerous societally valuable compounds.•Medicinally
relevant natural products include many clinical antibiotics.•Escherichia coli is a common …

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

Y Ye, T Ozaki, M Umemura, C Liu, A Minami… - Organic & …, 2019 - pubs.rsc.org
Asperipin-2a is a ribosomally synthesized and post-translationally modified peptide isolated
from Asperigillus flavus. Herein, we report the heterologous production of asperipin-2a and …

Aspergillus flavus secondary metabolites: more than just aflatoxins

JW Cary, MK Gilbert, MD Lebar, R Majumdar… - Food Safety, 2018 - jstage.jst.go.jp
Aspergillus flavus is best known for producing the family of potent carcinogenic secondary
metabolites known as aflatoxins. However, this opportunistic plant and animal pathogen …

Discovery of novel fungal RiPP biosynthetic pathways and their application for the development of peptide therapeutics

E Vogt, M Künzler - Applied microbiology and biotechnology, 2019 - Springer
Bioactive peptide natural products are an important source of therapeutics. Prominent
examples are the antibiotic penicillin and the immunosuppressant cyclosporine which are …