Diabetic retinopathy remains the major cause of blindness among working age adults.
Although a number of metabolic abnormalities have been associated with its development …

The purpose of this study was to investigate whether inhibition of DNA (cytosine-5)-
methyltransferase 1 (DNMT-1) alleviated ferroptosis through nuclear receptor coactivator 4 …

Diabetes is a severe threat to global health. Almost 500 million people live with diabetes
worldwide. Most of them have type 2 diabetes (T2D). T2D patients are at risk of developing …

Type 2 diabetes (T2D) is a major chronic healthcare concern worldwide. Emerging evidence
suggests that a histone-modification-mediated epigenetic mechanism underlies T2D …

DNA and histone proteins define the structure and composition of chromatin. Histone
posttranslational modifications (PTMs) are covalent chemical groups capable of modeling …

Background Epigenetic modifications, particularly histone acetylation-deacetylation and its
related enzymes, such as sirtuin 1 (SIRT1) deacetylase, may have substantial roles in the …

A healthy diet improves life expectancy and helps to prevent common chronic diseases such
as type 2 diabetes (T2D) and obesity. The mechanisms driving these effects are not fully …

Aims/hypothesis Subcutaneous adipocyte hypertrophy is associated with insulin resistance
and increased risk of type 2 diabetes, and predicts its future development independent of …

Aim To explore the relationship between genomic DNA methylation and diabetic chronic
complications. Methods 299 patients with type 2 diabetes mellitus (T2DM) hospitalized in the …

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, with its
prevalence linked to both genetic predisposition and environmental factors. Epigenetic …