Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Sleep disorders are a group of conditions that affect the ability to sleep well on a regular
basis and cause significant impairments in social and occupational functions. Although …

Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …

Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal
gland and locally in the retina following a circadian rhythm, with low levels during the day …

Melatonin, through its different receptors, has pleiotropic functions in mammalian brain.
Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated …

Melatonin receptors (MT1 and MT2 in humans) are family AG protein–coupled receptors that
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …

Melatonin is an ancient molecule that is evident in high concentrations in various tissues
throughout the body. It can be separated into two pools; one of which is synthesized by the …

Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and
metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals …