Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

The placenta and decidua interact dynamically to enable embryonic and fetal development.
Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester …

Exome-sequencing studies have generally been underpowered to identify deleterious
alleles with a large effect on complex traits as such alleles are mostly rare. Because the …

Fetal growth restriction is a major determinant of perinatal morbidity and mortality. Screening
for fetal growth restriction is a key element of prenatal care but it is recognized to be …

Background Fetal growth restriction is a major determinant of perinatal morbidity and
mortality. This condition has no gold standard definition, but a widely used proxy is delivery …

Delta-like non-canonical Notch ligand 1 (DLK1) is a cleavable single-pass transmembrane
protein and a member of the Notch/Delta/Serrate family. It is paternally expressed and …

Transmission of epigenetic information between generations occurs in nematodes, flies and
plants, mediated by specialised small RNA pathways, modified histones and DNA …

In the 1980s, mouse nuclear transplantation experiments revealed that both male and
female parental genomes are required for successful development to term (;). This non …

Imprinted genes display parent-of-origin-specific expression with this epigenetic system of
regulation found exclusively in therian mammals. Historically, defined imprinted gene …