Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

A coordinated balance between the positive and negative regulation of pattern-recognition
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …

In recent years, researchers have devoted much attention to the diverse roles of
macrophages and their contributions to tissue development, wound healing, and …

Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …

Our understanding of the genetic basis of systemic lupus erythematosus has progressed
rapidly in recent years. While many genetic polymorphisms have been associated with …

Inflammasomes form as the result of the intracellular presence of danger-associated
molecular patterns and mediate the release of active IL-1β, which influences a variety of …

PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and
functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling …