Knee osteoarthritis (KOA) is a common chronic debilitating disease with an estimated
prevalence of 23.9% in the general adult population. The condition is characterised by joint …

Today, the most frequent chronic musculoskeletal disorder and the leading cause of
disability in the elderly is osteoarthritis (OA). Approximately 43 million people in the United …

Importance Most clinical guidelines do not recommend platelet-rich plasma (PRP) for knee
osteoarthritis (OA) because of lack of high-quality evidence on efficacy for symptoms and …

Objective To develop concise, up-to-date, patient-focused, evidence-based, expert
consensus guidelines for the management of knee osteoarthritis (OA), intended to inform …

The objective was to develop evidence-based recommendations and a research and
educational agenda for the non-pharmacological management of hip and knee osteoarthritis …

Objective Mechanical factors, in particular increased medial knee joint load, are believed to
be important in the structural progression of knee osteoarthritis. This study evaluated the …

Background: MIV-711 is a novel selective cathepsin K inhibitor with beneficial effects on
bone and cartilage in preclinical osteoarthritis models. Objective: To evaluate the efficacy …

Osteoarthritis of the knee causes pain, limits activity, and impairs quality of life. Although it
cannot be cured, advances in understanding and treatment have improved the outlook for …

Background As knee osteoarthritis (OA) cannot be cured, treatments that slow structural
disease progression are a priority. Knee muscle activation has a potential role in OA …

Osteoarthritis (OA) is the most common type of arthritis found in the United States' population
and is also the most common disease of joints in adults throughout the world with the knee …