Synonymous mutations are often assumed to be neutral with respect to fitness because they
do not alter the encoded amino acid and so cannot be “seen” by natural selection. Yet a …

Despite efforts from a range of disciplines, our ability to predict and combat the evolution of
antibiotic resistance in pathogenic bacteria is limited. This is because resistance evolution …

Evolution of large asexual cell populations underlies∼ 30% of deaths worldwide, including
those caused by bacteria, fungi, parasites, and cancer. However, the dynamics underlying …

It is not known whether evolution will usually be rapid enough to allow a species to adapt
and persist in a deteriorating environment. We tracked the eco-evolutionary dynamics of …

At a glance, most species seem adapted to the environment in which they live. Yet species
relentlessly evolve, and populations within species evolve in different ways. Evolution, as it …

When large asexual populations adapt, competition between simultaneously segregating
mutations slows the rate of adaptation and restricts the set of mutations that eventually fix …

Our lack of total understanding of the intricacies of how enzymes behave has constrained
our ability to robustly engineer substrate specificity. Furthermore, the mechanisms of natural …

The fitness effects of synonymous mutations, nucleotide changes that do not alter the
encoded amino acid, have often been assumed to be neutral, but a growing body of …

The fitness effects of mutations are central to evolution, yet have begun to be characterized
in detail only recently. Site-directed mutagenesis is a powerful tool for achieving this goal …

We discuss the dynamics of adaptive evolution in asexual (clonal) populations. The classical
'periodic selection'model of clonal evolution assumed that beneficial mutations are very rare …