Cancer can be defined as an irregular functioning of the cell cycle that results in a
progressive loss of cell differentiation and uncontrolled cell growth. Moreover, despite …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

A general strategy was developed for the synthesis of new fully decorated 1, 2, 3-triazoles
(5a-m & 6a-e) containing coumarine and sulfonyl-benzimidazole from 3-(2-((1-methyl-1H …

An emerging interest for the application of periodate in the synthesis of active
pharmaceutical ingredients (APIs) and for the valorization of renewable feedstock is …

Cancer, characterized by a deregulation of the cell cycle which mainly results in a
progressive loss of cellular differentiation and uncontrolled cellular growth, remains a …

The therapeutic potential of the benzimidazole nucleus has been recognized since 1944,
and it is an important heterocycle system due to its presence in a wide range of bioactive …

Background Triazole is an important heterocyclic moiety that occupies a unique position in
heterocyclic chemistry, due to its large number of biological activities. It exists in two isomeric …

Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …

The tri-component synthesis of novel chiral benzimidazole Mannich bases, by reaction
between benzimidazole, aqueous 30% formaldehyde and an amine, the biological …

A new series of benzimidazole‐oxindole hybrids 8a–x was discovered as dual cyclin‐
dependent kinase (CDK2) and glycogen synthase kinase‐3‐beta (GSK‐3β) inhibitors with …