As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Sarcopenia, obesity and their coexistence, obese sarcopenia (OBSP) as well as
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Non-alcoholic fatty liver disease (NAFLD) has reached epidemic proportions, affecting an
estimated one-quarter of the world's adult population. Multiple organ systems have been …

The close relationship between the metabolic syndrome (MetS) and nonalcoholic fatty liver
disease (NAFLD) is well described in the literature. 1, 2 Indeed, due to this strong …

Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and
promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads …

Objective Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism
and systemic insulin resistance, which is partly mediated by altered secretion of liver …

Neutral lipids in the form of triacylglycerol (TAG) have emerged as critical regulators of
cellular energy balance, lipid homeostasis, growth, development and stress response in …