Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …

Review of myeloperoxidase supporting optimal microbicidal activity in the phagosomes of
human neutrophils. Successful immune defense requires integration of multiple effector …

Research over the past 5 years has demonstrated that immunologic activation of mouse
macrophages induces the activity of nitric oxide synthase, which oxidizes a guanidino …

Infection by bacteria, parasites or viruses and tissue inflammation such as gastritis, hepatitis
and colitis are recognized risk factors for human cancers at various sites. Nitric oxide (NO) …

The formation of nitric oxide (NO) from the amino acid L-arginine not only explains the
biological properties of the so-called endothelium-derived relaxing factor (EDRF) but also …

Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types
and organ systems. In the cardiovascular system, NO is an important determinant of basal …

NADPH diaphorase histochemistry selectively labels a number of discrete populations of
neurons throughout the nervous system. This simple and robust technique has been used in …

Research which started more than a decade ago in such diverse fields as receptor-mediated
increases in cyclic GMP levels in the central nervous system [1], the search for nitrate …

Even six years ago a review of nitric oxide in biology would have been very brief but, after
the initial reports in 1987 of the necessary role of nitric oxide in vascular muscle relaxation …

Understanding of the organization and function of a newly identified neuronal messenger
molecule, nitric oxide, has progressed rapidly. Nitric oxide synthase has been purified and …