Hypercoagulability in hemoglobinopathies: Decoding the thrombotic threat

R Bou‐Fakhredin, MD Cappellini… - American Journal of …, 2025 - Wiley Online Library
Beta (β)‐thalassemia and sickle cell disease (SCD) are characterized by a hypercoagulable
state, which can significantly influence organ complication and disease severity. While red …

A Compact Differential Dynamic Microscopy-based Device (cDDM): An Approach Tool for Early Detection of Hypercoagulable State in Transfusion-Dependent-β …

T Petiwathayakorn, N Paradee… - ACS Applied Bio …, 2024 - ACS Publications
β-Thalassemia especially transfusion-dependent thalassemia (TDT) associates with a
hypercoagulable state, which is the main cause of thromboembolic events (TEE). Plasma …

[HTML][HTML] Green Tea Epigallocatechin 3-Gallate Reduced Platelet Aggregation and Improved Anticoagulant Proteins in Patients with Transfusion-Dependent β …

T Petiwathayakorn, S Hantrakool, K Settakorn… - Foods, 2024 - mdpi.com
Patients with transfusion-dependent β-thalassemia (TDT) with iron overload have been
linked to hypercoagulability and increased platelet (PLT) activation that causes thrombosis …

[HTML][HTML] Protein C and S levels in patients with Thalassemia intermedia

NS Mohammed - Journal of Medicine and Life, 2022 - ncbi.nlm.nih.gov
This study was conducted to assess the level of proteins C and S in patients with
thalassemia intermedia from the Thalassemia Center in Erbil, Iraq. This study aimed to …

[HTML][HTML] Natural Anticoagulant Protein Levels in Patients With Beta-Thalassemia Major: A Case-Control Study

A Ahmadi, S Hosseini, A Dorgalaleh… - Journal of …, 2024 - ncbi.nlm.nih.gov
Background β-thalassemia is a group of inherited blood disorders that affect the production
of β-globin chains, leading to the reduction or absence of these chains. One of the …

[HTML][HTML] Venous Thromboembolism Risk Assessment among Beta-thalassemia Patients

HA Abo-Elwafa, LM Youseff, RA Mahmoud… - Journal of Applied …, 2023 - journals.lww.com
BACKGROUND: Thromboembolic (TE) disorders are among the most common
complications of beta-thalassemia. We designed this cross-sectional study to investigate the …

Consumption of Green Tea Extract Tablets Improved Anticoagulant Proteins and Reduced Platelet Aggregation in Transfusion-Dependent β-Thalassemia Patients

T Petiwathayakorn, S Hantrakool, K Settakorn… - 2023 - researchsquare.com
Hypercoagulability and increased platelet activation have been associated with iron-
overloaded β− thalassemia patients resulting in thrombosis. Iron chelators, antiplatelet and …

[PDF][PDF] D-Dimer Assessment as a Marker of Hypercoagulabilty in Egyptian Thalassemia Patients

OMK Mikhaiel, MF Mohamed, MR El-Masry, MA Fateen… - iscientific.org
Beta thalassemia is a prevalent form of hereditary haemolytic anaemia that is frequently
observed in the Mediterranean region. The prevalence of thromboembolism among patients …

Post Splenectomy Protein C Levels in Beta Thalassaemia Major Patients

A Niaz, K Tauseef, M Zahid, H Zafar, A Nafisa… - Journal of Haematology …, 2022 - jhscr.org
Results: The mean protein C values in non-splenectomized and splenectomized patients
were 62.11±9.65% and 41.64±6.37% respectively with a significant difference by …

[PDF][PDF] Do Fibrinogen Levels Serve as Indicator of Hepatic Iron Overload in Patients with High Transfusion Regimes Due to a Hematologic Disease

P Fecher, V Wiegering… - J Blood Disord Ther, 2021 - article.scholarena.com
Despite some major improvements in treating beta thalassemia in the past, it remains a
challenge to avoid the various complications which go along with iron overload. We …