The novel coronavirus SARS-CoV-2 enters into the human body mainly through the ACE2+
TMPRSS2+ nasal epithelial cells. The initial host response to this pathogen occurs in a …

Summary Mannose‐binding lectin (MBL), collectin‐10, collectin‐11, and the ficolins (ficolin‐
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …

The humoral arm of innate immunity includes diverse molecules with antibody-like functions,
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

Mannose-binding lectin (MBL) is a pattern recognition molecule of the innate immune
system. It belongs to the collectin family of proteins in which lectin (carbohydrate …

Innate immunity is the earliest response to invading microbes and acts to contain infection in
the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal …

IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …

Mannose-binding lectin (MBL) is a versatile macromolecule, embodying functional
characteristics of IgM, IgG and C1q. It might be particularly important in the early stages of a …

There are many links between the complement system and the autoimmune disease
systemic lupus erythematosus (SLE). Soon after the identification of antinuclear antibodies …

When the adaptive immune response is either immature or compromised, the innate
immune system constitutes the principle defense against infection. Mannose-binding lectin …