Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

Opioids remain among the most effective pain-relieving therapeutics. However, their long-
term use is limited due to the development of tolerance and potential for addiction. For many …

Nerve injury‐induced change in gene expression in primary sensory neurons of dorsal root
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Opioids are the gold standard for pharmacological treatment of neuropathic pain, but their
analgesic effects are unsatisfactory in part due to nerve injury–induced downregulation of …

Nav1. 3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are
closely associated with neuropathic pain. It can be up-regulated following nerve injury, but …

Activation of the mechanistic/mammalian target of rapamycin (mTOR) kinase in models of
acute and chronic pain is strongly implicated in mediating enhanced translation and …

Metastatic bone tumor-induced changes in gene transcription and translation in pain-related
regions of the nervous system may participate in the development and maintenance of bone …

Abstract Transient receptor melastatin 2 (TRPM2) is a nonselective Ca2+‐permeable cation
channel highly expressed in brain and other tissues. Studies showed that TRPM2 …

Electro-acupuncture (EA) has been used for clinic analgesia for many years. However, its
mechanisms are not fully understood. We recently reported that AXL, a tyrosine kinase …