A novel view on an old drug, 5-fluorouracil: an unexpected RNA modifier with intriguing impact on cancer cell fate

M Chalabi-Dchar, T Fenouil, C Machon, A Vincent… - NAR …, 2021 - academic.oup.com
Fluorouracil (5-FU) is a chemotherapeutic drug widely used to treat patients with solid
tumours, such as colorectal and pancreatic cancers. Colorectal cancer (CRC) is the second …

SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis

N Swain, M Thakur, J Pathak… - Journal of Oral and …, 2020 - journals.lww.com
Embryonic stem cells provide their major contribution to embryogenesis through formation of
germ layers as they have pluripotency potential and capacity for self-renewal. Retention of …

Deep learning based time-to-event analysis with PET, CT and joint PET/CT for head and neck cancer prognosis

Y Wang, E Lombardo, M Avanzo, S Zschaek… - Computer Methods and …, 2022 - Elsevier
Objectives Recent studies have shown that deep learning based on pre-treatment positron
emission tomography (PET) or computed tomography (CT) is promising for distant …

Cancer stem cells enrichment with surface markers CD271 and CD44 in human head and neck squamous cell carcinomas

OA Elkashty, G Abu Elghanam, X Su, Y Liu… - …, 2020 - academic.oup.com
Head and neck squamous cell carcinoma (HNSCC) has a poor 5-year survival rate of 50%.
One potential reason for treatment failure is the presence of cancer stem cells (CSCs) …

Curcumin-encapsulated nanomicelles improve cellular uptake and cytotoxicity in cisplatin-resistant human oral cancer cells

VM Kumbar, U Muddapur, A Bin Muhsinah… - Journal of Functional …, 2022 - mdpi.com
Oral cancer has a high mortality rate, which is mostly determined by the stage of the disease
at the time of admission. Around half of all patients with oral cancer report with advanced …

Therapeutic advancements in metal and metal oxide nanoparticle-based radiosensitization for head and neck cancer therapy

P Dubey, M Sertorio, V Takiar - Cancers, 2022 - mdpi.com
Simple Summary Though radiation therapy remains a primary modality for head and neck
cancer (HNC) management, the collateral damage to normal surrounding tissues and tumor …

Influence of implant‐specific radiation doses on peri‐implant hard and soft tissue: An observational pilot study

N Neckel, P Wagendorf, C Sachse… - Clinical Oral …, 2021 - Wiley Online Library
Objectives The aim of this study was to investigate the influence of real implant‐bed‐specific
radiation doses on peri‐implant tissue health in head and neck cancer (HNC) patients after …

Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer

K Brennan, A Espín-Pérez, S Chang, N Bedi… - Genome Medicine, 2023 - Springer
Background The prognosis for patients with head and neck cancer (HNC) is poor and has
improved little in recent decades, partially due to lack of therapeutic options. To identify …

Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma

OA Elkashty, SD Tran - British Journal of Cancer, 2020 - nature.com
Background Head and neck squamous cell carcinomas (HNSCC) are malignant neoplasms
with poor prognosis. Treatment-resistant cancer stem cell (CSC) is one reason for treatment …

Comparison of deep learning networks for fully automated head and neck tumor delineation on multi-centric PET/CT images

Y Wang, E Lombardo, L Huang, M Avanzo, G Fanetti… - Radiation …, 2024 - Springer
Objectives Deep learning-based auto-segmentation of head and neck cancer (HNC) tumors
is expected to have better reproducibility than manual delineation. Positron emission …