The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism
The zinc finger CCHC-type (ZCCHC) superfamily proteins, characterized with the consensus
sequence C-X2-C-X4-H-X4-C, are accepted to have high-affinity binding to single-stranded …
sequence C-X2-C-X4-H-X4-C, are accepted to have high-affinity binding to single-stranded …
A structure-free method for quantifying conformational flexibility in proteins
All proteins sample a range of conformations at physiologic temperatures and this inherent
flexibility enables them to carry out their prescribed functions. A comprehensive …
flexibility enables them to carry out their prescribed functions. A comprehensive …
The mysterious RAMP proteins and their roles in small RNA‐based immunity
A new class of prokaryotic RNA binding proteins called Repeat Associated Mysterious
Proteins (RAMPs), has recently been identified. These proteins play key roles in a novel type …
Proteins (RAMPs), has recently been identified. These proteins play key roles in a novel type …
Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3′-splice site recognition
Y Zhang, T Madl, I Bagdiul, T Kern… - Nucleic acids …, 2013 - academic.oup.com
Recognition of the 3′-splice site is a key step in pre-mRNA splicing and accomplished by a
dynamic complex comprising splicing factor 1 (SF1) and the U2 snRNP auxiliary factor 65 …
dynamic complex comprising splicing factor 1 (SF1) and the U2 snRNP auxiliary factor 65 …
U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs
Degenerate splice site sequences mark the intron boundaries of pre-mRNA transcripts in
multicellular eukaryotes. The essential pre-mRNA splicing factor U2AF65 is faced with the …
multicellular eukaryotes. The essential pre-mRNA splicing factor U2AF65 is faced with the …
Structure of phosphorylated SF1 bound to U2AF65 in an essential splicing factor complex
The essential splicing factors U2AF 65 and SF1 cooperatively bind consensus sequences at
the 3′ end of introns. Phosphorylation of SF1 on a highly conserved" SPSP" motif …
the 3′ end of introns. Phosphorylation of SF1 on a highly conserved" SPSP" motif …
Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1
T-cell intracellular antigen-1 (TIA-1) regulates developmental and stress-responsive
pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA …
pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA …
Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility
C Wang, A Ahlford, N Laxman, G Nordmark… - Genes & …, 2013 - nature.com
The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic
lupus erythematosus (SLE). To identify the sequence variants that are able to account for the …
lupus erythematosus (SLE). To identify the sequence variants that are able to account for the …
Branch point identification and sequence requirements for intron splicing in Plasmodium falciparum
X Zhang, CA Tolzmann, M Melcher, BJ Haas… - Eukaryotic …, 2011 - Am Soc Microbiol
Splicing of mRNA is an ancient and evolutionarily conserved process in eukaryotic
organisms, but intron-exon structures vary. Plasmodium falciparum has an extreme AT …
organisms, but intron-exon structures vary. Plasmodium falciparum has an extreme AT …
SF1 phosphorylation enhances specific binding to U2AF65 and reduces binding to 3′-splice-site RNA
Abstract Splicing factor 1 (SF1) recognizes 3′ splice sites of the major class of introns as a
ternary complex with U2AF 65 and U2AF 35 splicing factors. A conserved SPSP motif in a …
ternary complex with U2AF 65 and U2AF 35 splicing factors. A conserved SPSP motif in a …