The development of the vertebrate body axis relies on the activity of different populations of
axial progenitors, including neuromesodermal progenitors. Currently, the term …

Cnidarians are fascinating creatures at the base of metazoan evolution possessing an
almost unlimited regeneration capacity that has attracted the interest of researchers, from …

Communication in bilaterian nervous systems is mediated by electrical and secreted signals;
however, the evolutionary origin and relation of neurons to other secretory cell types has not …

Hydra's almost unlimited regenerative potential is based on Wnt signaling, but so far it is
unknown how the injury stimulus is transmitted to discrete patterning fates in head and foot …

Transcription factors are crucial drivers of cellular differentiation during animal development
and often share ancient evolutionary origins. The T-box transcription factor Brachyury plays …

Among non-bilaterian animals, a larval apical sensory organ with integrated neurons is only
found in cnidarians. Within cnidarians, an apical organ with a ciliary tuft is mainly found in …

Conserved cis-regulatory elements (CREs) control Engrailed-, Pax2-, and dachshund-
related gene expression networks directing the formation and function of corresponding …

Background The recent combination of genomics and single cell transcriptomics has
allowed to assess a variety of non-conventional model organisms in much more depth …

Cnidarians are the only non-bilaterian group to evolve ciliated larvae with an apical sensory
organ, which is possibly homologous to the apical organs of bilaterian primary larvae. Here …

Studies across a diverse group of metazoan embryos indicate that Wnt signaling often
activates the transcription factor Sp5, forming a signaling 'cassette'that plays critical roles in …