Background A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of
vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed …

Objectives To assess the overall effect of vitamin D supplementation on risk of acute
respiratory tract infection, and to identify factors modifying this effect. Design Systematic …

Vitamin D (VitD) is a prohormone most noted for the regulation of calcium and phosphate
levels in circulation, and thus of bone metabolism. Inflammatory and immune cells not only …

Background A previous aggregate data meta-analysis of randomised controlled trials
showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring …

Background: Vitamin D deficiency has been shown to be independently associated with
increased risk of viral acute respiratory infection (ARI) in a number of observational studies …

Background: Randomised controlled trials (RCTs) exploring the potential of vitamin D to
prevent acute respiratory infections have yielded mixed results. Individual participant data …

Background A large number of observational studies have reported harmful effects of low 25-
hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic …

Vitamin D, in addition to its classical functions in bone homeostasis, has a modulatory and
regulatory role in multiple processes, including host defense, inflammation, immunity, and …

Acute respiratory tract infections (ARIs) are a leading cause of ill-health and death globally.
Individual or multiple micronutrients have been shown to modulate immune function and …

Background Several clinical trials of vitamin D to prevent asthma exacerbation and improve
asthma control have been conducted in children and adults, but a meta‐analysis restricted …