The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

The Hedgehog (Hh) pathway is activated in some human cancers, including
medulloblastoma. The glioma-associated oncogene homolog (GLI) transcription factors are …

In humans, blood Classical CD14+ monocytes contribute to host defense by secreting large
amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation …

Lipopolysaccharides (LPSs) are a major component of Gram-negative bacterial cell wall and
play an important role in promoting intestinal inflammatory responses. Recent studies have …

Arsenic has been used for ages as a therapeutic agent. Currently, it is an FDA approved
drug to treat acute promyelocytic leukemia where it leads to degradation of the PML–RAR …

Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus.
Our understanding of PEL is poor and therefore treatment strategies are lacking. To address …

Multiple myeloma (MM) displays an NFκB activity-related gene expression signature and
about 20% of primary MM samples harbor genetic alterations conducive to intrinsic NFκB …

Candidiasis is one of the most frequent nosocomial infections affecting an increasing
number of at-risk patients. Candida albicans remains the most frequent causative agent of …

The preclinical compounds Bay 11-7082 and parthenolide trigger apoptosis, an effect
contributing to their antiinflammatory action. The substances interfere with the activation and …

The families of protein tyrosine phosphatases (PTP s) and protein tyrosine kinases (PTK s)
function in a coordinated manner to regulate signal transduction events that are critical for …