The nervous system, in addition to be a target for steroid hormones, is the source of a variety
of neuroactive steroids, which are synthesized and metabolized by neurons and glial cells …

Autism spectrum disorders (ASDs) and autistic traits in the general population may share
genetic susceptibility factors. In this study, we investigated such potential overlap based on …

Interestingly, more males are diagnosed with autism spectrum disorder (ASD) than females,
yet the mechanism behind this difference is unclear. Genes on the sex chromosomes and …

Although many studies indicate the interplay of genetic and environmental factors in the
etiology of autism spectrum disorder (ASD), our limited understanding of the underlying …

Abstract Background Bisphenol A (BPA) has been linked to susceptibility to autism spectrum
disorder (ASD). Our recent studies have shown that prenatal BPA exposure disrupted ASD …

Examining sex differences in the brain has been historically contentious but is nonetheless
important for advancing mental health for both girls and boys. Unfortunately, females in …

The enzymatic complex 5α-reductase (5α-R) and 3α/3β-hydroxysteroid oxidoreductase
(HSOR) is expressed in the nervous system, where it transforms progesterone (PROG) and …

Though the etiology of autism spectrum disorder (ASD) remains largely unknown, recent
findings suggest that hormone dysregulation within the prenatal environment, in conjunction …

Background Numerous studies have highlighted the elevated degree of comorbidity
associated with autism spectrum disorder (ASD). These comorbid conditions may add …

Sex steroid receptors have received much interest as potential mediators of human
behaviors and mental disorders. Candidate gene association studies have identified about …