Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …

Despite intensive research extending back to the 1930s, when the first synthetic antimalarial
drugs made their appearance, the repertoire of clinically licensed formulations remains very …

This systematic review elaborates the concepts and impacts of border malaria, particularly
on the emergence and spread of Plasmodium falciparum and Plasmodium vivax multidrug …

Background Plasmodium falciparum resistance to anti-malarial drugs remains a major
obstacle to the control of malaria. In 2001 Tanzania replaced chloroquine (CQ) with …

Background Chloroquine (CQ) was the cornerstone of anti-malarial treatment in Africa for
almost 50 years, but has been widely withdrawn due to the emergence and spread of …

Evolutionary biologists have largely left the search for solutions to the drug resistance crisis
to biomedical scientists, physicians, veterinarians and public health specialists. We believe …

Drug-resistant pathogens emerge faster than new drugs come out of drug discovery
pipelines. Current and future drug options should therefore be better protected, requiring a …

Abstract Background In Nigeria, despite the change in National malaria drug policy to
artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance …

Malaria, a leading parasitic disease, inflicts an enormous toll on human lives and is caused
by protozoal parasites belonging to the genus Plasmodium. Antimalarial drugs targeting …

Molecular surveillance of drug resistance markers through time provides crucial information
on genomic adaptations, especially in parasite populations exposed to changing drug …