[HTML][HTML] 'Spikeopathy': COVID-19 spike protein is pathogenic, from both virus and vaccine mRNA

PI Parry, A Lefringhausen, C Turni, CJ Neil, R Cosford… - Biomedicines, 2023 - mdpi.com
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to
society. The production of 'safe and effective'vaccines was a key public health target. Sadly …

Can SARS-CoV-2 infection lead to neurodegeneration and Parkinson's disease?

L Krey, MK Huber, GU Höglinger, F Wegner - Brain Sciences, 2021 - mdpi.com
The SARS-CoV-2 pandemic has affected the daily life of the worldwide population since
2020. Links between the newly discovered viral infection and the pathogenesis of …

Amyloidogenesis of SARS-CoV-2 spike protein

S Nystrom, P Hammarstrom - Journal of the American Chemical …, 2022 - ACS Publications
SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny
similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances …

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration

D Idrees, V Kumar - Biochemical and biophysical research communications, 2021 - Elsevier
The post-infection of COVID-19 includes a myriad of neurologic symptoms including
neurodegeneration. Protein aggregation in brain can be considered as one of the important …

Decoding clinical biomarker space of COVID-19: Exploring matrix factorization-based feature selection methods

F Saberi-Movahed, M Mohammadifard… - Computers in biology …, 2022 - Elsevier
One of the most critical challenges in managing complex diseases like COVID-19 is to
establish an intelligent triage system that can optimize the clinical decision-making at the …

Spike Protein Fragments Promote Alzheimer's Amyloidogenesis

S Cao, Z Song, J Rong, N Andrikopoulos… - … Applied Materials & …, 2023 - ACS Publications
Alzheimer's disease (AD) is a major cause of dementia inducing memory loss, cognitive
decline, and mortality among the aging population. While the amyloid aggregation of …

SARS-CoV-2 spike protein S1 domain accelerates α-synuclein phosphorylation and aggregation in cellular models of synucleinopathy

J Wang, L Dai, M Deng, T Xiao, Z Zhang… - Molecular …, 2024 - Springer
The 2019 novel coronavirus disease (COVID-19) is an infectious disease that began to
spread globally since 2019. Some COVID-19 patients have neurological complications …

Amyloid and hydrogel formation of a peptide sequence from a coronavirus spike protein

V Castelletto, IW Hamley - Acs Nano, 2022 - ACS Publications
We demonstrate that a conserved coronavirus spike protein peptide forms amyloid
structures, differing from the native helical conformation and not predicted by amyloid …

COVID-19 associated nervous system manifestations

F Khatoon, K Prasad, V Kumar - Sleep medicine, 2022 - Elsevier
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic in the last year …

Amyloid peptides with antimicrobial and/or microbial agglutination activity

D Chen, X Liu, Y Chen, H Lin - Applied Microbiology and Biotechnology, 2022 - Springer
Microbe (including bacteria, fungi, and virus) infection in brains is associated with amyloid
fibril deposit and neurodegeneration. Increasing findings suggest that amyloid proteins, like …