The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Lactic acid production has been regarded as a mechanism by which malignant cells escape
immunosurveillance. Recent technological advances in mass spectrometry and the use of …

Increasing evidence indicates that immunotherapy is hindered by a hostile tumor
microenvironment (TME) featured with deprivation of critical nutrients and pooling of …

Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and
immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Recent advances in immunotherapy have affirmed the curative potential of T cell-based
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …

T cell subsets adapt and rewire their metabolism according to their functions and
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …