Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
International union of basic and clinical pharmacology. CI. Structures and small molecule modulators of mammalian adenylyl cyclases
Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
[HTML][HTML] Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling
SE Anton, C Kayser, I Maiellaro, K Nemec, J Möller… - Cell, 2022 - cell.com
G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
[HTML][HTML] Vertebrate cells differentially interpret ciliary and extraciliary cAMP
Hedgehog pathway components and select G protein-coupled receptors (GPCRs) localize
to the primary cilium, an organelle specialized for signal transduction. We investigated …
to the primary cilium, an organelle specialized for signal transduction. We investigated …
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms
KF Ostrom, JE LaVigne, TF Brust… - Physiological …, 2022 - journals.physiology.org
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …
Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract
The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …
cAMP: from long-range second messenger to nanodomain signalling
N Musheshe, M Schmidt, M Zaccolo - Trends in pharmacological sciences, 2018 - cell.com
How cAMP generates hormone-specific effects has been debated for many decades.
Fluorescence resonance energy transfer (FRET)-based sensors for cAMP allow real-time …
Fluorescence resonance energy transfer (FRET)-based sensors for cAMP allow real-time …
Primary cilia: cell and molecular mechanosensors directing whole tissue function
Primary cilia are immotile, microtubule-based organelles extending from the surface of
nearly every mammalian cell. Mechanical stimulation causes deflection of the primary cilium …
nearly every mammalian cell. Mechanical stimulation causes deflection of the primary cilium …
cAMP signaling compartmentation: adenylyl cyclases as anchors of dynamic signaling complexes
TB Johnstone, SR Agarwal, RD Harvey… - Molecular pharmacology, 2018 - ASPET
It is widely accepted that cAMP signaling is compartmentalized within cells. However, our
knowledge of how receptors, cAMP signaling enzymes, effectors, and other key proteins …
knowledge of how receptors, cAMP signaling enzymes, effectors, and other key proteins …
Phosphodiesterases in heart and vessels-From Physiology to Diseases
Q Fu, Y Wang, C Yan, YK Xiang - Physiological Reviews, 2023 - journals.physiology.org
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …