Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …

The transforming growth factor beta (TGF-β) is a crucial cytokine that get increasing concern
in recent years to treat human diseases. This signal controls multiple cellular responses …

Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …

Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …

Overexpression of the TGFβ pathway impairs the proliferation of the hematopoietic stem and
progenitor cells (HSPCs) pool in Fanconi anemia (FA). TGFβ promotes the expression of …

Murine hematopoietic stem and progenitor cells (HSPCs) are commonly used as model
systems during gene therapeutic retroviral vector development and preclinical biosafety …

The dual tumor-suppressive and-promoting functions of TGF-β signaling has made its
targeting challenging. We examined the effects of TGF-β depletion by AVID200/BMS …

We introduce drexml, a command line tool and Python package for rational data-driven drug
repurposing. The package employs machine learning and mechanistic signal transduction …

ABSTRACT The coronavirus disease 2019 (COVID-19) has resulted in approximately 7.0
million fatalities between 2019 and 2022, underscoring a pressing need for comprehensive …

Background/Aim: Patients with radiation sensitive Fanconi anemia (FA) are presenting with
cancers of the oral cavity, oropharynx, and other anatomic locations. Materials and Methods …