The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

The nucleosome assembly protein Nap1 is used extensively in the chromatin field to
reconstitute nucleosomal templates for structural and functional studies. Beyond its role in …

Gene activator proteins comprise distinct DNA-binding and transcriptional activation
domains (ADs). Because few ADs have been described, we tested domains tiling all yeast …

Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …

Sequences rich in glutamine (Q) and asparagine (N) residues often fail to fold at the
monomer level. This, coupled to their unusual hydrogen-bonding abilities, provides the …

The tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) is a tumor
suppressor. Heterozygosity for defective SDH subunit genes predisposes to familial …

Here we describe the establishment and prediction utilities for a novel nine-amino-acid
transactivation domain, 9aa TAD, that is common to the transactivation domains of a large …

Motivation: The diverse microarray datasets that have become available over the past
several years represent a rich opportunity and challenge for biological data mining. Many …

A major obstacle in analyzing gene function in apicomplexan parasites is the absence of a
practical regulatable expression system. Here, we identified functional transcriptional …

We have previously shown that Aspergillus fumigatus is able to grow in zinc‐limiting media
and that this ability is regulated at transcriptional level by both the availability of zinc and pH …