The duality of PRDM proteins: epigenetic and structural perspectives

F Di Tullio, M Schwarz, H Zorgati, S Mzoughi… - The FEBS …, 2022 - Wiley Online Library
PRDF1 and RIZ1 homology domain containing (PRDMs) are a subfamily of Krüppel‐like
zinc finger proteins controlling key processes in metazoan development and in cancer …

Emerging mesenchymal tumour types and biases in the era of ubiquitous sequencing

EA Towery, DJ Papke - Journal of Clinical Pathology, 2023 - jcp.bmj.com
New tumour types are being described at increasing frequency, and most new tumour types
are now identified via retrospective review of next-generation sequencing data. This …

Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome

A Bettiol, M Becatti, E Silvestri… - Clinical & …, 2021 - academic.oup.com
Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Superficial CD34-positive fibroblastic tumor: a clinicopathologic, immunohistochemical, and molecular study of 59 cases

WJ Anderson, F Mertens… - The American Journal …, 2022 - journals.lww.com
Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare soft tissue neoplasm that
shows overlapping features with PRDM10-rearranged soft tissue tumor (PRDM10-STT). This …

Superficial CD34‐positive fibroblastic tumor and PRDM10‐rearranged soft tissue tumor are overlapping entities: a comprehensive study of 20 cases

R Perret, M Michal, RA Carr, V Velasco… - …, 2021 - Wiley Online Library
Aims Superficial CD34‐positive fibroblastic tumor (SCD34FT) and PRDM10‐rearranged soft
tissue tumor (PRDM10‐STT) are rare mesenchymal tumors. These lesions have …

[HTML][HTML] Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue …

F Puls, JM Carter, N Pillay, TA McCulloch, VP Sumathi… - Modern Pathology, 2022 - Elsevier
Superficial CD34-positive fibroblastic tumor (SCD34FT) is a recently recognized soft tissue
tumor that is considered to be of borderline malignancy. The pathogenesis of this tumor …

[HTML][HTML] Detection of sarcoma fusions by a next-generation sequencing based–ligation-dependent multiplex RT-PCR assay

MD Lanic, F Le Loarer, V Rainville, V Sater, M Viennot… - Modern Pathology, 2022 - Elsevier
Morphological, immunohistochemical, and molecular methods often need to be combined
for accurate diagnosis and optimal clinical management of sarcomas. Here, we have …

[HTML][HTML] The peroxisome proliferator-activated receptor agonist rosiglitazone specifically represses tumour metastatic potential in chromatin inaccessibility-mediated …

QY Chen, XB Huang, YJ Zhao, HG Wang, JB Wang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Efforts to prevent recurrence in gastric cancer (GC) patients are limited by
current incomplete understanding of the pathological mechanisms. The present study aimed …

[HTML][HTML] PRDM10 RCC: a Birt-Hogg-Dubé-like syndrome associated with lipoma and highly penetrant, aggressive renal tumors morphologically resembling type 2 …

LS Schmidt, CD Vocke, CJ Ricketts, Z Blake, KK Choo… - Urology, 2023 - Elsevier
Objective To characterize the clinical manifestations and genetic basis of a familial cancer
syndrome in patients with lipomas and Birt-Hogg-Dubé-like clinical manifestations including …

Global translation during early development depends on the essential transcription factor PRDM10

BY Han, MKY Seah, IR Brooks, DHP Quek… - Nature …, 2020 - nature.com
Members of the PR/SET domain-containing (PRDM) family of zinc finger transcriptional
regulators play diverse developmental roles. PRDM10 is a yet uncharacterized family …