▪ Abstract Sorting of transmembrane proteins to endosomes and lysosomes is mediated by
signals present within the cytosolic domains of the proteins. Most signals consist of short …

Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …

The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …

The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …

▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins
between various compartments of the secretory and endocytic systems. Clathrin forms a …

The GGA proteins are a family of ubiquitously expressed, Arf-dependent clathrin adaptors
that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network …

The Golgi-localized, γ-ear–containing, adenosine diphosphate ribosylation factor–binding
proteins (GGAs) are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) …

Clathrin-mediated vesicular trafficking events underpin the vectorial transfer of
macromolecules between several eukaryotic membrane-bound compartments. Classical …

The Golgi complex is the membrane-bound organelle that lies at the center of the secretory
pathway. Its main functions are to maintain cellular lipid homeostasis, to orchestrate protein …