Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

The balance between immune effector cells and immunosuppressive cells and how this
regulates the tumor microenvironment has been well described. A significant contribution of …

Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Regulatory B cells (Bregs) modulate immune responses predominantly, although not
exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of …

Vitamin D (VitD) is a prohormone most noted for the regulation of calcium and phosphate
levels in circulation, and thus of bone metabolism. Inflammatory and immune cells not only …

The classical function of Vitamin D, which involves mineral balance and skeletal
maintenance, has been known for many years. With the discovery of vitamin D receptors in …

Purpose: To characterize the role of B cells on human papilloma virus (HPV)-associated
cancer patient outcomes and determine the effects of radiation and PD-1 blockade on B-cell …

Success with B cell depletion using rituximab has proven the concept that B lineage cells
represent a valid target for the treatment of autoimmune diseases, and has promoted the …

Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It
plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display …

The immune system, innate and adaptive, is a highly evolved and complex network,
essential for promoting survival in an environment full of potential pathogens, while …