Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …

Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …

Pluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced
PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for …