Recent advances in targeted therapies in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …
for younger patients over the last several decades has improved nearly sixfold with the …
IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
Ivosidenib and Azacitidine in IDH1-Mutated Acute Myeloid Leukemia
P Montesinos, C Recher, S Vives… - … England Journal of …, 2022 - Mass Medical Soc
Background The combination of ivosidenib—an inhibitor of mutant isocitrate dehydrogenase
1 (IDH1)—and azacitidine showed encouraging clinical activity in a phase 1b trial involving …
1 (IDH1)—and azacitidine showed encouraging clinical activity in a phase 1b trial involving …
Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
CD DiNardo, EM Stein, S de Botton… - … England Journal of …, 2018 - Mass Medical Soc
Background Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) occur in 6 to
10% of patients with acute myeloid leukemia (AML). Ivosidenib (AG-120) is an oral, targeted …
10% of patients with acute myeloid leukemia (AML). Ivosidenib (AG-120) is an oral, targeted …
The significance of mitochondrial dysfunction in cancer
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
[HTML][HTML] An overview: the diversified role of mitochondria in cancer metabolism
Y Sun, Y Guo, X Shi, X Chen, W Feng… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia
EM Stein, CD DiNardo, DA Pollyea… - Blood, The Journal …, 2017 - ashpublications.org
Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in∼ 12% of patients with
acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2 …
acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2 …
An epigenetic role of mitochondria in cancer
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
Ivosidenib or enasidenib combined with intensive chemotherapy in patients with newly diagnosed AML: a phase 1 study
EM Stein, CD DiNardo, AT Fathi… - Blood, The Journal …, 2021 - ashpublications.org
Abstract Ivosidenib (AG-120) and enasidenib (AG-221) are targeted oral inhibitors of the
mutant isocitrate dehydrogenase (mIDH) 1 and 2 enzymes, respectively. Given their …
mutant isocitrate dehydrogenase (mIDH) 1 and 2 enzymes, respectively. Given their …
The emerging hallmarks of cancer metabolism
NN Pavlova, CB Thompson - Cell metabolism, 2016 - cell.com
Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …
and indirect consequence of oncogenic mutations. A common feature of cancer cell …