Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?
For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …
Control of sleep and wakefulness
This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …
Wakefulness promoting systems cause low-voltage, fast activity in the …
Epidemiology and etiology of Parkinson's disease: a review of the evidence
The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …
genetic and environmental factors. Incidence and prevalence estimates vary to a large …
Identifying prodromal Parkinson's disease: pre‐motor disorders in Parkinson's disease
Increasing recognition that Parkinson's disease (PD) may start outside of the substantia
nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor …
nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor …
Parkinson's disease: clinical features and diagnosis
J Jankovic - Journal of neurology, neurosurgery & psychiatry, 2008 - jnnp.bmj.com
Objective: Parkinson's disease (PD) is a progressive neurological disorder characterised by
a large number of motor and non-motor features that can impact on function to a variable …
a large number of motor and non-motor features that can impact on function to a variable …
Sleep and sleep disorders in older adults
K Crowley - Neuropsychology review, 2011 - Springer
A common but significant change associated with aging is a profound disruption to the daily
sleep-wake cycle. It has been estimated that as many as 50% of older adults complain about …
sleep-wake cycle. It has been estimated that as many as 50% of older adults complain about …
The spectrum of nonmotor symptoms in early Parkinson disease
Objective: Nonmotor symptoms (NMS) are common in patients with established Parkinson
disease (PD) but their frequency in early PD has not been extensively studied. Our aim was …
disease (PD) but their frequency in early PD has not been extensively studied. Our aim was …
The concept of prodromal Parkinson's disease
P Mahlknecht, K Seppi… - Journal of Parkinson's …, 2015 - content.iospress.com
Parkinson's disease (PD) is currently clinically defined by a set of cardinal motor features
centred on the presence of bradykinesia and at least one additional motor symptom out of …
centred on the presence of bradykinesia and at least one additional motor symptom out of …
Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder
BF Boeve, MH Silber, TJ Ferman, SC Lin… - Sleep medicine, 2013 - Elsevier
Objective To determine the pathologic substrates in patients with rapid eye movement
(REM) sleep behavior disorder (RBD) with or without a coexisting neurologic disorder …
(REM) sleep behavior disorder (RBD) with or without a coexisting neurologic disorder …
REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder‐neurodegenerative disease association, evolving concepts …
BF Boeve - Annals of the new York Academy of Sciences, 2010 - Wiley Online Library
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by
vivid, often frightening dreams associated with simple or complex motor behavior during …
vivid, often frightening dreams associated with simple or complex motor behavior during …