Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …

Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …

Objective: The objective of the study was to develop clinical practice guidelines for the
diagnosis of Cushing's syndrome. Participants: The Task Force included a chair, selected by …

One of the most consistent findings in the biology of depression is an altered activity of the
hypothalamic–pituitary–adrenal (HPA) axis. However, data concerning this issue have never …

Objective: The objective of the study was to develop clinical practice guidelines for the
diagnosis of Cushing's syndrome. Participants: The Task Force included a chair, selected by …

Context: Incidental benign adrenocortical adenomas, adrenal incidentalomas are found in
4.5% of abdominal computed tomography scans, with the incidence increasing to 10% in …

Importance Cushing syndrome is defined as a prolonged increase in plasma cortisol levels
that is not due to a physiological etiology. Although the most frequent cause of Cushing …

The pathogenesis of declining bone mineral density, a universal feature of ageing, is not
fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in …

Context: Subclinical hypercortisolism (SH) is a condition of biochemical cortisol excess
without the classical signs or symptoms of overt hypercortisolism. It is thought to be present …

Clinical decision making for patients with suspect hypercortisolism involves a complex
diagnostic assessment. Cushing's syndrome remains one of the most challenging endocrine …