Cerebral small vessel disease, hypertension, and vascular contributions to cognitive impairment and dementia

AH Hainsworth, HS Markus, JA Schneider - Hypertension, 2024 - Am Heart Assoc
Hypertension-associated cerebral small vessel disease is a common finding in older people.
Strongly associated with age and hypertension, small vessel disease is found at autopsy in …

Diabetic microvascular disease in non-classical beds: the hidden impact beyond the retina, the kidney, and the peripheral nerves

D Mauricio, M Gratacòs, J Franch-Nadal - Cardiovascular Diabetology, 2023 - Springer
Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by
structural and functional abnormalities within the intricate network of microvessels beyond …

Cerebral microinfarcts revisited: Detection, causes, and clinical relevance

J Huang, GJ Biessels, FE de Leeuw… - … Journal of Stroke, 2024 - journals.sagepub.com
Cerebral microinfarcts (CMIs) are small ischemic lesions invisible to the naked eye at brain
autopsy, while the larger ones (0.5–4 mm in diameter) have been visualized in-vivo on …

Blood–brain barrier disruption and perivascular spaces in small vessel disease and neurodegenerative diseases: a review on MRI methods and insights

PHM Voorter, M van Dinther, WJ Jansen… - Journal of Magnetic …, 2024 - Wiley Online Library
Perivascular spaces (PVS) and blood–brain barrier (BBB) disruption are two key features of
cerebral small vessel disease (cSVD) and neurodegenerative diseases that have been …

White matter microstructure alterations in type 2 diabetes mellitus and its correlation with cerebral small vessel disease and cognitive performance

Y Liu, Y Jiang, W Du, B Gao, J Gao, S Hu, Q Song… - Scientific Reports, 2024 - nature.com
Microstructural abnormalities of white matter fiber tracts are considered as one of the
etiology of diabetes-induced neurological disorders. We explored the cerebral white matter …

Cerebral small vessel disease: a review of the pathophysiological mechanisms

Y Hannawi - Translational Stroke Research, 2023 - Springer
Cerebral small vessel disease (cSVD) refers to the age-dependent pathological processes
involving the brain small vessels and leading to vascular cognitive impairment, intracerebral …

Contrast‐agent‐based perfusion MRI code repository and testing framework: ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)

PJ van Houdt, S Ragunathan, M Berks… - Magnetic resonance …, 2024 - Wiley Online Library
Purpose Software has a substantial impact on quantitative perfusion MRI values. The lack of
generally accepted implementations, code sharing and transparent testing reduces …

Prevention of vascular contributions to cognitive impairment and dementia: the role of physical activity and exercise

E Dao, CK Barha, J Zou, N Wei, T Liu-Ambrose - Stroke, 2024 - Am Heart Assoc
Vascular contributions to cognitive impairment and dementia, specifically cerebral small
vessel disease (CSVD), are the second most common cause of dementia. Currently, there …

Current and future treatments of vascular cognitive impairment

BYM Ip, H Ko, BYK Lam, LWC Au, AYL Lau, J Huang… - Stroke, 2024 - Am Heart Assoc
Vascular cognitive impairment (VCI) traditionally encompasses a variety of cerebrovascular
pathologies that contribute to varying levels of cognitive impairment, ranging from subtle to …

Cerebral arterial stiffness is linked to white matter hyperintensities and perivascular spaces in older adults–A 4D flow MRI study

C Björnfot, A Eklund, J Larsson… - Journal of Cerebral …, 2024 - journals.sagepub.com
White matter hyperintensities (WMH), perivascular spaces (PVS) and lacunes are common
MRI features of small vessel disease (SVD). However, no shared underlying pathological …