Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …

Epidermal growth factor receptor (EGFR) has fundamental roles in normal physiology and
cancer, making it a rational target for cancer therapy. Surprisingly, however, inhibitors that …

The complex morphology of neurons, the specific requirements of synaptic
neurotransmission and the accompanying metabolic demands create a unique challenge for …

Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play
important roles in cancer development and progression, being deeply implicated in …

Mitochondrial homeostasis is regulated by a balance between mitochondrial biogenesis and
degradation. Emerging evidence suggests that mitophagy, a selective form of autophagy …

Autophagy is a highly regulated degradative process crucial for maintaining cell
homeostasis. This important catabolic mechanism can be nonspecific, but usually occurs …

Abstract The 3′, 5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase
(PKA) is a tetrameric holoenzyme comprising a set of two regulatory subunits (PKA-R) and …

Intracellular molecular pathways (IMPs) control all major events in the living cell. IMPs are
considered hotspots in biomedical sciences and thousands of IMPs have been discovered …

Although cells respond specifically to environments, how environmental identity is encoded
intracellularly is not understood. Here, we study this organization of information in budding …

The kinetic participation of macrophages is critical for inflammatory resolution and recovery
from myocardial infarction (MI), particularly with respect to the transition from the M1 to the …