Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

The use of implants that can electrically stimulate or record electrophysiological or
neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in …

Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

The constant dynamic movement of synapses and their components has emerged in the last
decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein …

The human brain contains more than 100 trillion (1014) synaptic connections, which form all
of its neural circuits. Neuroscientists have long been interested in how this complex synaptic …

Synapses are asymmetric cellular adhesions that are critical for nervous system
development and function, but the mechanisms that induce their formation are not well …

The establishment of neural circuitry requires vast numbers of synapses to be generated
during a specific window of brain development, but it is not known why the developing …

Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

Stem cell transplantation promises new hope for the treatment of stroke although significant
questions remain about how the grafted cells elicit their effects. One hypothesis is that …