Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

Current advancements in antiretroviral therapy (ART) have turned HIV-1 infection into a
chronic and manageable disease. However, treatment is only effective until HIV-1 develops …

Proteolytic processing of viral polyproteins is essential for retrovirus infectivity. Retroviral
proteases (PR) become activated during or after assembly of the immature, non-infectious …

Proteases are a major enzyme group playing important roles in a wide variety of biological
processes in life forms ranging from viruses to mammalians. The aberrant activity of …

Antiretroviral therapy has led to a significant decrease in human immunodeficiency virus
(HIV)-related mortality. Approved antiretroviral drugs target different steps of the viral life …

HIV-1 has been the target of intensive research at the molecular and biochemical levels for>
25 years. Collectively, this work has led to a detailed understanding of viral replication and …

Publisher Summary This chapter describes the assembly, release, and maturation of human
immunodeficiency virus type 1 (HIV-1). The HIV‐1 replication cycle has the potential to …

Processing of the GagPol polyprotein precursor of human immunodeficiency virus type 1
(HIV-1) is a critical step in viral assembly and replication. The HIV-1 protease (PR) is …

Abstract Human Immunodeficiency Virus (HIV) maturation plays an essential role in the viral
life cycle by enabling the generation of mature infectious virus particles through proteolytic …

Considerable success has been achieved in the treatment of HIV-1 infection, and more than
two-dozen antiretroviral drugs are available targeting several distinct steps in the viral …