Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Abstracts Taxol is one of the most effective anticancer drugs in the world that is widely used
in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic …

Tetrahydropapaverine (THP) and papaverine are plant natural products with clinically
significant roles. THP is a precursor in the production of the drugs atracurium and …

Isosteviol is a tetracyclic diterpenoid obtained by hydrolysis of stevioside. Due to its unique
molecular skeleton and extensive pharmacological activities, isosteviol has attracted more …

Cancer is undeniably a major health risk factor that is growing rapidly globally despite
promising medicinal and pharmaceutical development. Treatment of cancer remains an …

Natural drugs have been transformed and optimized during the long process of evolution.
These compounds play a very important role in the protection of human health and treatment …

Cancer is a fatal disease that causes around 9 million deaths annually in developing and
developed countries worldwide. Recently, natural products as alternatives for chemical …

Endophytes are defined as microorganisms which live in plant tissues without causing any
apparent negative effects to the host plant. Endophytes have been considered rich sources …

Alkaloids are a type of secondary metabolites that can be found in different parts of plants.
This group of compounds is diverse and can be divided into nine subgroups: pyridine …

UV and gamma irradiation mutagenesis was applied on Aspergillus fumigatus and
Alternaria tenuissima in order to improve their producing ability of paclitaxel. Among the …