Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
C Settembre, RM Perera - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …
through macromolecular breakdown to coordinate programmes for growth, repair and stress …
Autophagy in liver diseases: a review
The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …
The autophagy–NAD axis in longevity and disease
Autophagy is an intracellular degradation pathway that recycles subcellular components to
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
[HTML][HTML] Autophagy promotes cell survival by maintaining NAD levels
Autophagy is an essential catabolic process that promotes the clearance of surplus or
damaged intracellular components. Loss of autophagy in age-related human pathologies …
damaged intracellular components. Loss of autophagy in age-related human pathologies …
ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its
recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases) …
recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases) …
Compromised autophagy and neurodegenerative diseases
FM Menzies, A Fleming, DC Rubinsztein - Nature Reviews …, 2015 - nature.com
Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …
A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
NPC1-mTORC1 signaling couples cholesterol sensing to organelle homeostasis and is a targetable pathway in Niemann-Pick type C
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
Development of autophagy inducers in clinical medicine
Defects in autophagy have been linked to a wide range of medical illnesses, including
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …