To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Extracellular binding proteins or antagonists are important factors that modulate ligands in
the transforming growth factor (TGF‐β) family. While the interplay between antagonists and …

The current research was aimed at probing into the role of long noncoding RNA (lncRNA)
PVT1 in the pathogenesis of glioma and the regulatory mechanism of PVT1/miR-128 …

Over 20 different growth factors belonging to the bone morphogenetic proteins (BMPs)
family have been identified, that were initially discovered as growth factors that promote …

Glioblastomas are the most prevalent and lethal primary brain tumor and are comprised of
hierarchies with self-renewing cancer stem cells (CSCs) at the apex. Like neural stem cells …

BioXpress is a gene expression and cancer association database in which the expression
levels are mapped to genes using RNA-seq data obtained from The Cancer Genome Atlas …

Cancer cell survival, function and fate strongly depend on endoplasmic reticulum (ER)
proteostasis. Although previous studies have implicated the ER stress signaling network in …

Background Fibroblasts have important roles in the synthesis and remodeling of
extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal …

Background Tumors comprise a complex microenvironment of interacting malignant and
stromal cell types. Much of our understanding of the tumor microenvironment comes from in …

Simple Summary Cancer-associated fibroblasts (CAFs) are the major cellular component of
the tumor microenvironment and have been shown to stimulate tumor growth, epithelial-to …